Cluster 1 includes keywords such as 1p/19q, IDH mutation, low-grade gliomas, astrocytoma, diagnosis, oligodendroglioma, prediction, prognostic marker, prognostic value, prognostic significance, and survival, indicating that this cluster may be related to the prognostic factors and clinically related indicators of glioma patients. The gene discussed is IDH2; the disease is central nervous system cancer.