FLT3 and acute myeloid leukemia: In total, samples from 14 patients with AML were FLT3-ITD-positive, and these blasts were found to be nearly five times more sensitive to CPX-351-induced cytotoxicity than FLT3-ITD-negative AML blasts (mean IC50 values = 0.29:0.058 μM and 1.32:0.26 μM, respectively; p = 0.047 for difference).