Marsdenia tenacissima extract (MTE) at a concentration of 40 mg crude/mL notably upregulated the expression of ATF6, GRP-78, ATF4, xbp1, and CHOP in NSCLC PC-9 and H1975 cells, activated ERS while increasing ROS production, and upregulated immunogenic cell expression of death-related markers (ATP, HMGB1) and reduced MMP, thereby inducing apoptosis; in addition, MTE was shown to trigger ERS and immunogenic cell death by inhibiting tyrosine protein kinase receptor AXL activity (Yuan et al., 2023a). The gene discussed is HSPA5; the disease is non-small cell lung carcinoma.