HSPA5 and lung cancer: Fucoidan promoted tunicamycin expression and activated the ERS pathway in lung cancer A549 and H1975 cells, which promoted apoptosis by upregulating the GRP78 protein and its mediated caspase-3/poly ADP-ribose polymerase (PARP) apoptotic pathway; additionally, fucoidan has been synergized with cisplatin to induce apoptosis and decrease the toxic effects of cisplatin by enhancing the viability of cisplatin-treated cells (Hsu et al., 2018).