ATF4 and hepatocellular carcinoma: Compared with Konjac glucomannan (KGM) or 5-Fluorouracil (5-FU) alone, KGM combined with 5-FU notably induced apoptosis and suppressed cell proliferation and migration with inhibition of Toll-like receptor 4 (TLR4) expression to activate ERS and its mediated PERK/ATF4/CHOP signaling pathway in HCC HepG2 and Bel-7402 cells; moreover, KGM reversed the resistance of HCC to 5-FU by decreasing TLR4 in vivo experiments (Shi et al., 2022).