Wogonoside at 50 μM resulted in the activation of ERS in gastric cancer AGS and MKN-45 cells, increased levels of GRP78 and glucose regulated protein 94 (GRP94) proteins and activated the IRE1α pathway and its mediated TRAF2 and ASK1-related complexes, thereby activating the JNK signaling pathway and inducing apoptosis by enhancing Bax expression and reducing Bcl-2 expression (Gu et al., 2021). This evidence concerns the gene HSPA5 and gastric cancer.