CASP12 and gastric cancer: Kangfuxin at 1 μg/mL was able to promote GRP78 protein expression, accelerate ERS, upregulate CHOP and caspase-12 protein concentration, and increase the release of autophagy-related proteins Beclin-1 and LC3-II/LC3-I in gastric cancer SGC-7901 cells; the trend of ERS-induced apoptosis and cellular autophagy was the same, and cellular autophagy could not be activated even after ERS was inhibited, so it can be concluded that Kangfuxin promotes apoptosis by activating autophagy, which was carried out after promoting ERS (Chen et al., 2017).