EIF2AK3 and colorectal cancer: Osthole effectively upregulated the expression of GRP78, PERK, elF2α and CHOP proteins in colorectal cancer HT-29 cells at both 25 and 50 μM concentrations, activating ERS and promoting apoptosis, inducing autophagy and thus promoting apoptosis by upregulating the LC3-II/LC3-I ratio and downregulating p62 protein expression (Zhou et al., 2021).