ERN1 and gastric cancer: MKN-45 and AGS gastric cancer cell lines were treated with 7.8125, 15.625 and 31.25 μM myristicin, and the findings indicated that the expression of GRP78, the connector protein of ERS, phosphorylated IRE1α and PERK, and ATF6 were increased, while Myristicin upregulated caspase-12, the executor protein of ERS-triggered cell death, and triggered apoptosis (Song et al., 2023).