MAPK8 and colorectal carcinoma: Curcumin exhibited an IC50 value of 40.7 ± 0.5 μM, which led to the initiation of the ERS pathway and upregulated the expression of CHOP and jnk pathways in CRC HT-29 cells; moreover, curcumin could increase the concentration of Ca2+ in cells, facilitating the liberation of mitochondrial Cyt C and ultimately decreasing MMP and Bcl-2 expression levels and upregulating bax expression to induce apoptosis (Cao et al., 2013).