This may occur 1) when triglycerides found in chylomicrons are hydrolyzed by pancreatic lipase, leading to the production of free fatty acids and induction of free radical damage (Tsuang et al., 2009) or 2) through an indirect mechanism related to atypical antipsychotics, obesity, and insulin resistance (Yan et al., 2013). Here, PNLIP is linked to obesity due to melanocortin 4 receptor deficiency.