Regarding the apoptosis of podocytes and tubular cells, the current study’s findings showed that type 1 diabetes significantly upregulated the mRNA expression of proapoptotic markers FAS, FAS l, P53, BAX, and caspase-3 and downregulation in the antiapoptotic marker BCL2 that were in the same line with the previously obtained findings by Kumar et al. (2004), Sha et al. (2017), Gong et al. (2019), Ju et al. (2019), and Xu and Ren )2019). This evidence concerns the gene TP53 and type 1 diabetes mellitus.