CASP3 and type 1 diabetes mellitus: Type 1 diabetes induced a significant upregulation in the mean fold change of the relative mRNA expression of renal proapoptotic markers Fas, FasL, P53, caspase-3, BAX, and BAX/BCL2 and a significant downregulation in the antiapoptotic marker BCL2 compared with the control group (Figures 6A–G).