Type 1 diabetes induction caused a significant increase in the mean urine volume, serum urea level, serum creatinine level, urine microalbumin, 24 h creatinine clearance, and albumin excretion and a significant decrease in urine urea excretion and creatinine excretion at the 12th week as well as 4th week after diabetes induction in diabetic rats compared with control rats (Figures 2A-J). This evidence concerns the gene ALB and type 1 diabetes mellitus.