CRP and inflammatory bowel disease: Effenberger et al also employed in silico metabolomic modelling in 65 patients with IBD and similarly identified a higher abundance of butyrate production at baseline (1.7-fold) in remitters than in non-remitters at weeks 12 and 30 (defined by CDAI < 150, normal C-reactive protein [CRP], and fcal < 150mcg/g).