First, although we tried to use high IgE level, early infection age, and hospitalization to indicated children with atopic disease and severe bronchiolitis, we were unable to identify important covariates associated with developing asthma in child with severe bronchiolitis, such as virus subtype, family history of atopic disease, maternal asthma, and socioeconomic status which might alert the interpretations of our result [24, 28]. Here, IGHE is linked to infection.