STING1 and neoplasm: Intracellularly, the cyclic guanosine monophosphate-adenosine monophosphate (cGAS)-STING signaling pathway is repressed via promoter hypermethylation of the cGAS and STING genes, and can be rescued by KDM5i and AZA, leading to pro-inflammatory cytokine production, enhanced antigen presentation and tumor immunogenicity [130–132].