In the cancer-immunity cycle, the C–C motif chemokine receptor 7 (CCR7)-CCL19/CCL21 axis governs the entry of cDC1 and TN into the TdLN, while the C-X-C motif chemokine receptor 3 (CXCR3)-CXCL9/CXCL10 axis regulates the egress of T helper 1 (Th1) cells and CD8+ TSTs from the TdLN into the TIME. The gene discussed is CXCR3; the disease is cancer.