Given the strong correlation among the hub genes, we explored their shared pathways, and integration of GSEA data from the five hub genes revealed numerous inflammatory and immune-related signaling pathways closely related to SLE including IL6_JAK_STAT3_SIGNALING, INTERFERON_ALPHA_RESPONSE, and TNFA_SIGNALING_VIA_NFKB [45–47]. The gene discussed is NFKB1; the disease is systemic lupus erythematosus.