In addition, the results of the differential expression and co-expression analyses indicated that IFI27, MSRB2, and SCO2 may have counteractive regulatory effects when compared to FAM210B and LYRM7 in the progression of SLE, which was corroborated by the outcomes of immune infiltration and GSEA. The gene discussed is IFI27; the disease is systemic lupus erythematosus.