NLRP3 and asthma: Whilst we showed that NLRP3 expression in sputum is associated with features of severe neutrophilic asthma, whether increased ability for NLRP3 inflammasome priming and activation and IL-1β release are key features of immune cells in other phenotypes of severe or non-severe asthma, and whether inflammasome responses in immune cells from patients with asthma can be inhibited with MCC950, is unknown.