We have previously shown that airways NLRP3 inflammasome responses are associated with increased neutrophilic and eosinophilic inflammation in the airways in both experimental and clinical asthma [16, 27], and there are subjects with asthma and IL-5-, IL-17A-/F- and IL-25-high sputum cytokine profiles that have increased sputum eosinophil and neutrophil numbers [48, 49]. This evidence concerns the gene NLRP3 and asthma.