AR and breast cancer: FOXA1 contributes to the activation of androgen receptor (AR) signaling that drives the growth and survival of PCa cells through direct interaction with AR and also has an AR-independent role in regulating epithelial-mesenchymal transition (EMT)[38], FOXA1 binds to the DNA-binding domain of STAT2 and inhibits STAT2 DNA-binding activity, IFN signaling gene expression and the tumor immune response in PCa and BC [39].