CircRNAs are a class of noncoding RNAs and have been identified to be involved in multiple steps in tumor development, PTK2 exon-derived hsa_circ_0005273 promotes the proliferation and metastasis of BC cells by binding to miR-200a-3p to upregulate YAP1 expression and inhibit the Hippo pathway [26], and the interaction of circ-GALNT16 with p53 is enhanced to inhibit the proliferation and metastasis of colorectal cancer cells via the inhibition of Senp2-mediated hnRNPK desumoylation [27]. This evidence concerns the gene SENP2 and neoplasm.