Many members of the Forkhead Box protein family are associated with pancreatic metabolism and differentiation and the development of pancreatic cancer (PC), FOXO1 inhibition can mimic β-cell differentiation by downregulating β-cell-specific transcription and lead to abnormal expression of progenitor genes and the α-cell marker glucagon [36]. The gene discussed is FOXO1; the disease is pachyonychia congenita.