Levels of activated B cells, activated CD4 T cells, activated dendritic cells, CD56 bright natural killer cells, CD56dim natural killer cells, gamma delta T cells, immature B cells, myeloid-derived suppressor cells (MDSC), macrophages, mast cells, monocytes, natural killer T cells, natural killer cells, plasmacytoid dendritic cells, regulatory T cells, T-follicular helper cells, type 1 T helper cells, effector memory CD4 T cells and central memory CD4 T cells were higher in obesity samples than in normal control samples (Fig. 7A). The gene discussed is NCAM1; the disease is obesity due to melanocortin 4 receptor deficiency.