Finally, we chose the three highest scoring genes in each module to conduct Kaplan–Meier plot and identified that FSTL3 in C1_2, PKM and TMEM51 in C1_8, and SERPINC1 in C1 _10 were intricately linked to HCC patients’ outcome (P < 0.05, Figure S5D-F). This evidence concerns the gene TMEM51 and hepatocellular carcinoma.