TP53 and hepatocellular carcinoma: Figure S6A showed the 20 genes with the largest mutation frequencies in HCC, including TP53, TTN, and CTNNB1. We then compared the alterations in mutational frequencies between the two clusters and found that TP53 was more frequently mutated in C2, compared to C1, while the opposite was true for CTNNB1 (Figure S6B).