Most networks in HCC, particularly ITPR3, CATSPER1, and CACNB1, showed high levels of activation in the apoptotic and Epithelial-mesenchymal transition (EMT) signaling pathways, but consistent inhibition in the hormones Androgen receptor (AR), RAS/ Mitogen-activated protein kinases (MAPK), and Receptor tyrosine kinases (RTK) (Fig. 2D). The gene discussed is WNK2; the disease is hepatocellular carcinoma.