ICAM1 and type 2 diabetes mellitus: We have previously demonstrated that an increase in the expression of ICAM‐1 in regional synovial cells facilitates the recruitment of macrophages into the joint in the T2DM rat model.[16] Consistently, cell‐cell contact analysis by CellChat[29] revealed that macrophages were the most activated cell type in DOA, and the ICAM signaling during macrophage‐synovial cell interactions was strengthened in the DOA group (Figure S8, Supporting Information), which supports the hypothesis that elevated ICAM‐1 expression in the synovium may contribute to the regulation of macrophages.