In contrast, the influence of NETosis on host susceptibility to bacteria and survival in septic mice remains unchanged in PAD4‐deficient mice.[86] Nonetheless, PAD4‐deficient neutrophils exhibit impaired antibacterial activity against pathogens, such as Shigella flexneri and group A Streptococcus pyogenes, consequently exacerbating necrotizing fasciitis.[73] These investigations underscore the significance of NETs in treating virulent bacterial and fungal infections. This evidence concerns the gene PADI4 and fungal infectious disease.