This form of cell death differs from traditional necroptosis.[155] Some cases of necrosis may also be unrelated to RIPK1 and MLKL, as observed in myocardial necrosis induced by ischemia and oxidative stress, which act through the RIPK3‐Ca2+‐Calmodulin‐dependent protein kinase pathway.[156] Therefore, neutrophil lysis caused by CA‐MRSA could also be interpreted as RIPK3‐dependent necroptosis (Figure 6). This evidence concerns the gene RIPK3 and ischemia.