Methylation levels measured by bisulfite sequencing over the entire DNA (Spearman correlation coefficient [ρ = 0.48], p = 1.2 × 10−13) and at intermediate DNA methylation levels (8%–92%, p = 0.006), SMAD3 methylation was extremely correlated with asthma (ρ = 0.46, p = 0.009).22 The gene discussed is SMAD3; the disease is asthma.