AGT and abdominal aortic aneurysm: Subsequent infusion of angiotensin II, an established model of thoracic and abdominal aortic aneurysm (AAA) formation17, caused markedly diminished survival of homozygous mice compared to wild-type and heterozygous littermates (Fig. 5C), associated with significantly increased TAA development (Fig. 5D; Supplementary Fig. 9C), dissection (Fig. 5E) and rupture.