Furthermore, expression of the Tuft cell marker DCLK-1 (double cortin-like kinase-1) and IL-25, which is secreted by Tuft cells and regulates type 2 immune responses24,25, increased in a time-dependent manner (Fig. 4l) that coincided with the temporal kinetics of leukemia progression (Supplementary Fig. 1). This evidence concerns the gene DCLK1 and leukemia.