ITGAM and chronic myelogenous leukemia, BCR-ABL1 positive: These animals also had a nearly two-fold augmentation in spleen weights (Supplementary Fig. 1e) and an increase in the frequency (Supplementary Fig. 1f) and absolute number of CD11b+ Gr-1+ myeloid cells (Supplementary Fig. 1g) consistent with what is observed in CML in humans18,19.