YTHDF1 and pachyonychia congenita: It was found that the YTHDF1 expression was significantly up-regulated in the PC cell lines (LNCAP, DU145, and PC-3) compared to the RWPE-2 cells (P < 0.05), as well as in the LNCAP cells; the YTHDF1 expression was the highest (Fig. 1C).