YTHDC2 and pachyonychia congenita: Another study manifested that YTHDF1, YTHDC2, and YTHDF2 were up-regulated in PC, and had positive correlation with the Gleason grades of PC, as well as the m6A levels were higher in the LNCAP cells [26] Furthermore, m6A regulators are reported to have positive correlation with AR, and play important roles in PC progression [26].