These genes included 9 genes previously identified by our group to be differentially expressed in IL-7Rαlow EM CD8+ T cells and the most highly associated with chronological aging in healthy subjects as we previously reported (referred to as top IL-7Rαlow aging genes) as well as two inflammatory control genes (IRF1 and NLRX1) which were not found in the AD datasets though they have the potential to affect AD pathology [19, 27]. This evidence concerns the gene IRF1 and Alzheimer disease.