CD8A and dementia: Unbiased hierarchal clustering (Supplementary Fig. S3) was also performed, which demonstrated substantial portions of the MCI group and a small part of the dementia group clustered together with high expression levels of the top aging genes associated with IL-7Rα low EM CD8+ T cells (represented by the “top IL-7Rαlow aging genes” category in Supplementary Fig. S3).