The HAND2-AS1 gene methylation data were obtained from the cBioPortal, which showed a substantial increase in the promoter methylation level of HAND2-AS1 in many cancers as depicted in Fig. 11A. Meanwhile, the DNA methylation pattern and HAND2-AS1 mRNA expression were negatively correlated in COAD and READ (Fig. 11B). Here, HAND2 is linked to cancer.