The YY1 gene encodes the zinc-finger TF protein yin and yang 1 that interacts with the dystonia-associated gene THAP1 (Baumann et al., 2021; Domingo et al., 2021; Yellajoshyula, 2022; Zorzi et al., 2021) and activates the myelination gene expression program centered on the TF EGR2 (He et al., 2010), thus highlighting the crucial role of YY1 in central nervous system myelination. The gene discussed is YY1; the disease is Dystonia.