MAPT and Alzheimer disease: The early deposition of AD pathology in limbic thalamic nuclei and its relation to cognitive and behavioral symptoms (evidence summarized in section 6.1.1) may have implications for network models of the functional impact of AD pathology and for disease propagation models that incorporate a potential role of prion‐like spreading of misfolded amyloid beta and tau proteins in the brain connectome.99, 100