TLR4 and hyperuricemia: Lagotis brachystachya maxim, an herb commonly used in traditional Tibetan medicine for its ability to alleviate local inflammation, has been shown by Zhu et al. [58] to reduce hyperuricaemia by decreasing UA synthesis, enhancing UA excretion, and inhibiting the TLR4/MyD88/NLRP3 inflammasome signaling pathway.