Additionally, sex hormones, particularly estrogen and its receptors, including estrogen receptor 1 (ER1), estrogen receptor 2 (ER2), and G-protein-coupled estrogen receptor-30 (GPR30), have been implicated in the pathogenesis and progression of bladder cancer in females, as detailed in prior studies [22]. The gene discussed is GPER1; the disease is urinary bladder carcinoma.