Matrine has shown anti‐fibrotic properties in hepatic fibrosis,147 and in DbCM, it protects against fibrosis and recovers left ventricular (LV) by inhibiting TGF‐β1/R‐Smad signalling pathway, although it does not affect levels of nhibitory Smads like Smad7.146. The gene discussed is TGFB1; the disease is Hepatic fibrosis.