Several mechanisms have been proposed to explain this potential correlation: (1) ARID1A deficiency may increase PD‐L1 expression in tumour cells by activating the phosphatidylinositol 3 kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway in GC.79 The gene discussed is CD274; the disease is neoplasm.