In the context of neurodegenerative diseases, the accumulation of amyloid deposits of specific compositions of these amyloid proteins (in conjunction with other protein species) in defined brain regions is a pathological hallmark of these conditions—for instance, amyloid‐beta (Aβ) in Alzheimer's disease, alpha‐synuclein (⍺Syn) in Parkinson's disease, and prion proteins in prion disorders, among numerous others (Table 1). Here, SNCA is linked to early-onset autosomal dominant Alzheimer disease.