PDCD1 and glioblastoma: Furthermore, tumor re‐challenge experiments in this study demonstrated that the host developed acquired immune memory for glioblastoma after synergistic treatment combined with mechanical HIFU ablation and PD‐1 checkpoint blockade.[160] Since chemotherapy, HIFU and ICB have been widely used in the clinical treatment of tumors, their combination therapy may have great application prospects, especially mechanical HIFU.