A growing number of studies are focused on targeting non‐apoptotic pathways that regulate cell death to improve the efficiency of cancer treatment.[100, 101, 102, 103] Hence, mitochondrial‐targeting liposomal nanoparticles (termed as MLipRIR NPs) were synthesized via encapsulating the inhibitor of glutamate dehydrogenase 1 (GDH1), R162, and sonosensitizer, IR780, into a lipid bilayer (Figure 6e). Here, GLUD1 is linked to cancer.