Following ICD, the DAMPs release promoted DC maturation and CTL activation, and triggered rapid inflammatory activation with the upregulation of TNF‐α, IL‐6 and IFN‐γ levels in serum, subsequently leading to immune‐mediated tumor suppression.[100] Furthermore, a nanoplatform (RSL3@O2‐ICG NB) loaded with RAS‐selective lethality (RSL3, ferroptosis promoter), was constructed to enhance SDT and promote ferroptosis. This evidence concerns the gene TNF and neoplasm.