Furthermore, tumor re‐challenge experiments in this study demonstrated that the host developed acquired immune memory for glioblastoma after synergistic treatment combined with mechanical HIFU ablation and PD‐1 checkpoint blockade.[160] Since chemotherapy, HIFU and ICB have been widely used in the clinical treatment of tumors, their combination therapy may have great application prospects, especially mechanical HIFU. Here, PDCD1 is linked to neoplasm.