A study by Yu et al. [10] showed that rhein downregulates phosphorylated NF-κB, p65, IκBα, and IKKβ induced by LPS and reduces the activation of NF-κB by inhibiting the expression and phosphorylation of related proteins in the NF-κB signaling pathway, thereby inhibiting the transcription of NF-κB and p65; thus, rhein has a protective effect against acute kidney injury. Here, IKBKB is linked to acute kidney injury.