PRNP and early-onset autosomal dominant Alzheimer disease: Although the pathology-related proteins in multiple neurodegenerative diseases are different e.g. prion protein (PrP) in prion diseases, tau and Aβ in Alzheimer’s disease (AD), and synuclein in Parkinson’s disease (PD); one common feature of these maladies is the accumulation of oligomeric and amyloidogenic protein aggregates [1, 2].