To this end, in the current study, we used a combination of co-immunoprecipitation and mass spectrometry (MS) to compare the interactome rearrangements of neurodegenerative disease-linked proteins (PrP, synuclein, and tau) under basal and oxidative stress-induced conditions; and the impact of these findings on the understanding of pathophysiological processes. The gene discussed is PRNP; the disease is neurodegenerative disease.