Consistent with the data described above, evaluation of c-Myc expression by ddPCR showed that the high mRNA levels detected after activation of the Wnt pathway (TWS-119) decreased significantly upon treatment with ralimetinib (Fig. 8B), indicating that p38α inhibition reduces β-catenin transcriptional activity also in these complex CRC cell systems. This evidence concerns the gene MYC and colorectal carcinoma.