Necroptosis, which is mediated by receptor-interacting protein kinase 1 (RIPK1 or RIP1), RIPK3 (or RIP3), and the pseudokinase MLKL, promotes necrotic cell death and neuroinflammation in Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS), multiple sclerosis (MS), and PD [11–15]. Here, RIPK1 is linked to early-onset autosomal dominant Alzheimer disease.