ELISA assay revealed the concentration of IL-6 in the culture medium supernatant was elevated in the IDD cell model when contrasted with the NC group (P < 0.001), while both PPARγ and pioglitazone treatment both alone and in combination significantly decreased the IL-6 level (Fig. 2B, P < 0.05). This evidence concerns the gene PPARG and intervertebral disk degenerative disorder.