As a result, the inhibition of miR-96-5p caused a much lower NF-κB level in the nucleus compared with the IDD cell model (P < 0.05), while siPPARγ partially reversed the inhibition of nuclear translocation of NF-κB caused by miR-96-5p inhibitor (Fig. 7C, D, P < 0.05). Here, NFKB1 is linked to intervertebral disk degenerative disorder.