In addition, this study also clarified at the cellular level that inhibiting miR-96-5p and activating PPARγ in HNPCs could alleviate the apoptosis and inflammation of HNPCs in IDD, and silencing PPARγ could reverse the alleviation of IDD by miR-96-5p inhibition. The gene discussed is PPARG; the disease is intervertebral disk degenerative disorder.