LDHA and neoplasm: Reversion experiments performed on a subcutaneous tumor xenograft nude mouse model (with similar groups as the ones in the in vitro experiments) showed that the tumor size and growth in the GLUT3-KD group were significantly lower than those in the GLUT3-NC group; moreover, the tumor size and growth in the GLUT3-KD + LDHA-OE group did not significantly differ from those in the GLUT3-NC group (Fig. 7A–C).