Given that human psoriasis is mainly caused by the alteration of keratinocyte proliferation and differentiation programmes, we decided to further understand the role of lnc-RNA uc-291, its molecular interactor ACTL6A, and the epidermal differentiation genes FLG and LOR in this disorder, considering that the involvement of this molecular axis has just been elucidated in physiological differentiation conditions[34]. The gene discussed is FLG; the disease is psoriasis.