FLG and psoriasis: In general, these results confirmed that in a model similar to psoriasis, induced by cytokines, down-regulation of uc.291 correlates to an impaired expression of FLG and LOR. This may be due to the overexpression of ACTL6A and to its permanence on the chromatin of the EDC locus due to uc.291 down-regulation, resulting in inhibition of the transcription of differentiation genes (Fig. 4).