EGFR and Friedreich ataxia: Notably, those PIKK pathogenic mutation-enriched pathways could be clustered into 2 categories, one was proliferation-related pathways (e.g., RAS pathway, MAPK pathway, ERBB pathway, and PI3K-AKT pathway) and the other was DNA repair-related pathways, that is, Fanconi anemia (FA) and homologous recombination (HR) pathways (Fig. 3E).