Specifically, ATM-mutated ADC patients had lower macrophage (especially the M2 macrophage) infiltration while ATM-mutated SCC patients had less B cell and regulatory T cell (Treg) infiltrations; additionally, ATR-mutated ADC patients were associated with less CD4 + T cell and neutrophil infiltrations (Fig. 6F). This evidence concerns the gene ATM and AIDS dementia complex.