LAG3 expression was significantly upregulated in 8 tumors investigated in this study, including BRCA (tumor: 1.00 ± 1.60, normal: 0.20 ± 0.88, P = 1.1e-16), ESCA (tumor: 1.44 ± 1.51, normal: 0.85 ± 1.43, P = 5.6e-5), STES (tumor: 1.70 ± 1.51, normal: 0.78 ± 1.48, P = 5.4e-27), STAD (tumor: 1.81 ± 1.50, normal: 0.56 ± 1.63, P = 2.0e-19), HNSC (tumor: 1.80 ± 1.72, normal: – 0.11 ± 1.15, P = 3.0e-12), KIRC (tumor: 1.59 ± 1.86, normal: -0.96 ± 1.58, P = 2.7e-47), SKCM (tumor: 1.32 ± 2.15, normal: -0.22 ± 0.90, P = 1.8e-13), PAAD (tumor: 0.61 ± 1.22, normal: – 2.59 ± 1.50, P = 1.0e-48). This evidence concerns the gene LAG3 and neoplasm.