Subgroup analysis based on tumor type showed that higher expression of LAG3 was correlated with worse OS in patients with CESC (HR = 1.76, 95% CI 1.03–3.00, P = 0.038), LIHC (HR = 1.76, 95% CI 1.08–2.87, P = 0.024), and SKCM (HR = 1.92, 95% CI 1.15–3.22, P = 0.013). This evidence concerns the gene LAG3 and neoplasm.