At the same time, we found that HCIPS was closely related to OS in male patients, those aged < 60 years, those with tumor size ≥ 5 cm, those with liver cirrhosis, those with BCLC stage C, those with TNM stage III+IV, those with CEA ≥ 2.38 U/L, those with AFP ≥ 151.40 U/L, and those with CA199 < 22.64 U/L (all P < 0.05) (Fig. 6). The gene discussed is AFP; the disease is cirrhosis of liver.