We performed LASSO regression analysis and multivariate COX regression analysis on the patients in the training cohort and finally obtained five genes: ARHGAP1, ARHGAP8, ARHGAP10, ARHGAP25, and ARHGAP28, and then we constructed a risk prediction model for patients with osteosarcoma based on these five genes. This evidence concerns the gene ARHGAP10 and osteosarcoma.