Notably, in addition to involving neurological disorders such as Parkinson’s disease, Huntington’s disease and Alzheimer’s disease [31, 61], and our proteomics analysis also revealed that MSI2 depletion was closely connected to the lipid transport and metabolism process, inorganic ion transport and metabolism process, oxidative phosphorylation and especially the MAPK signaling pathway (Figs. 4 and 5). Here, MSI2 is linked to Huntington disease.