Analysis of IHC staining results for MSI2, HSPB1, p-HSPB1(Ser78) and Ki67 showed that MSI2 knockout could reduce the expression of HSPB1, p-HSPB1(Ser78) and the tumor proliferation capacity in transgenic CAC mice (Fig. 6F). The gene discussed is MSI2; the disease is neoplasm.