HSPB1 and colorectal carcinoma: However, the patients with high HSPB1 expression had worse prognoses in the CRC TCGA database (p = 0.00052), GSE17536 (p = 0.00013) and GSE14333 (p = 0.00063) datasets (Fig. 8B), and the patients with lower HSPB1 expression had better prognoses.