Given the pathogenic roles of MSI2 in tumor progression [21], as well as the protective roles of HSPs in ferroptosis [33–35, 37, 69], we demonstrated that MSI2 could regulate multiple HSPs to repress ferroptosis, especially the ferroptosis suppressor genes HSPB1 and HSPA5, as evidenced by previous studies [13, 34, 39]. The gene discussed is HSPA5; the disease is neoplasm.