Consistent with the results from TCGA in Fig. 1G, GSEA enrichment analysis of SW620 proteomics also suggested that MSI2 was involved in the regulation of other important signaling pathways, such as oxidative phosphorylation (NES=-2.0253), Huntington’s disease (NES=-1.9115), Parkinson’s disease (NES=-1.8789) and Alzheimer’s disease (NES=-1.7749) (Fig. 4J), and recent studies have also discovered that these neuro-degenerative diseases exhibited the key features of ferroptosis: lipid peroxidation and iron accumulation [54]. Here, MSI2 is linked to early-onset autosomal dominant Alzheimer disease.