Furthermore, the positive correlations between MSI2 and ferroptosis inhibitor genes in TCGA CRC datasets were further identified, and the positively correlated genes included BRD4 (R = 0.24, p = 6.8e-10), NFE2L2 (R = 0.56, p = 1.48e-51), STAT3 (R = 0.42, p = 1.89e-27), HSPA5 (R = 0.50, p = 6.93e-41), CREB1 (R = 0.68, p = 5.72e-84), SLC7A11 (R = 0.58, p = 6.44e-56), ATF4 (R = 0.24, p = 1.47e-09), FANCD2 (R = 0.35, p = 6.15e-19), CD44 (R = 0.31, p = 2.22e-15), HELLS (R = 0.47, p = 1.17e-34), CISD1 (R = 0.23, p = 1.29e-08) and SCD (R = 0.22, p = 4.87e-08) (Fig. 1I). The gene discussed is HELLS; the disease is colorectal carcinoma.