UBE2D3 and neoplasm: In addition, the in vivo roles of UBE2D3 as a regulator of oncogenesis were explored by subcutaneously implanting HCT116 cells in which UBE2D3 was or was not silenced in immunodeficient mice, ultimately revealing no significant differences in tumor size or intratumoral UBE2D3 expression (Fig. S7).