TNF and cancer: Of these targets, CDCP1 is reportedly associated with PI3K/AKT signaling(Khan et al. 2021), CMTM6 is a critical regulator of PD-L1 in a broad range of cancer cells(Burr et al. 2017), while UBE2D3 is linked to NF-κB signaling(Chen et al. 2017) and ADAM10 plays a role in TNF signaling(Arduise et al. 2008).