In an ischemic stroke model system, for example, the knockdown of ANRIL reportedly leads to the alleviation of neuroinflammation through the miR-671-5p/NF-κB axis(Deng et al. 2022), whereas circANRIL silencing can suppress NF-κB and JNK/p38 pathway activity via promoting miR-9 upregulation, shielding renal tubular epithelial cells against damage induced by lipopolysaccharide exposure(Deng et al. 2019). This evidence concerns the gene MAPK8 and ischemic stroke.