In a previous in vitro study comparing the cytokine profile of KRAS mutant, BRAF mutant, and BRAF/KRAS wild-type Caco2 CRC cells, we found an increased expression of a Th1 related cytokine (CXCL10), and decreased expression of Th2 related cytokines (CCL2 and TGFB1) in BRAF-mutated cells, while the opposite pattern was shown for KRAS-mutated cells [37]. This evidence concerns the gene BRAF and colorectal carcinoma.