HMGB2 and cancer: We found that interferon-induced genes (IFIT1 and IFI44L, for example) and HLA-related genes (HLA-A, HLA-B and HLA-C) were all up-regulated in cancer clone B (Fig. 5f), and correspondingly T cell state 8, which is colocalized with cancer clone B, had high expression of HMGB2, HLA-B and HLA-C (Fig. 5f), indicating well-stimulated T cell response33,34.