ACE and hypertensive disorder: In patients with newly diagnosed hypertension, five antihypertensive drug classes [angiotensin-converting enzyme inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), beta-blockers (BBs), calcium channel blockers (CCBs) and diuretics (Ds)] are widely recommended by clinical guidelines as first-line blood pressure lowering drugs, either in combination or as monotherapy3–8.