Among the DEGs that show the most extreme and significant expression changes before and after musical stimuli in ACD patients are the down-regulated genes GIGYF1 (P-value = 6.3 × 10–8), and MNT (P-value = 1.5 × 10–7), ADAMTSL4 (P-value = 4.6 × 10–5) and the up-regulated gene TMEM38B (P-value = 1.0 × 10–7) (Fig. 2E). This evidence concerns the gene GIGYF1 and granular corneal dystrophy type II.