PPARG and obesity due to melanocortin 4 receptor deficiency: Thymoquinone (TQ), a natural quinone (C10H12O2), has been reported to possess anti-inflammatory, antioxidant, antidiabetic, and antihyperlipidemic properties and to reduce the differentiation of adipose-derived stem cells (ADSCs) to adipocytes through inhibiting the expression of PPARγ and FASN.58 By regulating PPAR-γ, a key target of lipid metabolism, TQ may be a potential anti-obesity compound.