For EOC, in contrast with normal ovarian tissue, the tumor initiation cells (TICs) of HGSOC manifested an apparently higher level of transferrin receptor 1 (TFR1, the iron importer) and an obviously lowered level of ferroportin (FPN, the iron efflux pump), eventually resulting in the excessive accumulation of intracellular iron [29]. The gene discussed is SLC40A1; the disease is neoplasm.