INS and type 1 diabetes mellitus: Genetic silencing of Kelch-like ECH-associated protein 1 (Keap1), a negative regulator of Nrf2, activates Nrf2 to inhibit T-cell infiltration within or near the islets, ameliorate impairment of insulin secretion and prevent the development of T1D in mice [19], and suppression of the Nrf2 signaling accelerates T1D progression [20].