In comparison, the mitochondrial membranes of tumor cells are hyperpolarized with a membrane potential as low as −220 mV, which promotes tumor cells migration and invasion.[36, 37] In addition, membrane polarization directly affects mitochondrial outer membrane permeability and limits the release of cytochrome c (cyt c) and the activation of apoptotic pathways, subsequently causing the chemoresistance of tumor cells.[37, 38] Belfield et al.[21c] proposed a strategy to alleviate chemoresistance by modulating mitochondrial pH with PAGs. Here, CYCS is linked to neoplasm.